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Review of extranodal extension grading for esophageal cancer: three-dimensional radiologic, surgical and pathologic findings

ENE histologic features. (A) INI: tumor remain within the original lymph node without any sign of ENE (hematoxylin-eosin stain; original magnification, ×20). (B) Grade 1 shows tumor extending ≤1 mm beyond the nodal capsule (indicated by the yellow line on the schematic) (hematoxylin-eosin stain; original magnification, ×5). (C) Grade 2 shows tumor extending >1 mm beyond the nodal capsule (yellow line on the schematic) (hematoxylin-eosin stain; original magnification, ×5). (D) Grade 3 shows metastatic lymph nodes in which carcinoma extend beyond the original nodal area (dotted circle), accompanied by complete destruction of nodal architecture (hematoxylin-eosin stain; original magnification, ×5).

A case report of esophageal squamous cell carcinoma with schwannoma-like features: from diagnosis to surgical management

Histology of the resected specimen. (A,B) The resected specimens showed a moderately differentiated invasive squamous cell carcinoma with (C) lymph node metastases (H&E). (D,E) Reactive connective tissue was identified around the squamous cell carcinoma, but there was no discrete neural proliferation (H&E). Images were acquired at 4× (A,C) and 20× (B,D,E) objective magnification. Original images were color balanced and cropped for presentation. No other digital alterations were performed. H&E, hematoxylin and eosin.

A review of esophageal cancer research: emerging trends, progress and perspectives

Doxorubicin’s mechanisms for inducing apoptosis in rapidly dividing cells.

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles

October 2, 2025 — Wolters Kluwer Health announced a new collaboration with AME Publishing Company, an Open Access publisher specializing in medical journals and books, headquartered in Hong Kong, China.

The First Impact Factor for Annals of Esophagus: 0.6

We are pleased to announce that the Annals of Esophagus (AOE) has attained its first impact factor for the 2024 citation year: 0.6

Here, we would like to extend our heartfelt gratitude to all our Editorial Team Members, Guest Editors, authors, and reviewers for their valuable contributions.

Annals of Esophagus 2024 CiteScore Released: 1

We are pleased to announce that Annals of Esophagus (AOE) has achieved its 2024 CiteScore: 1, ranking 317 out of 568 journals in the Surgery category and 128 out of 173 journals in the Gastroenterology category. This milestone underscores our ongoing commitment to publishing impactful research in the field.

Reviewer of the Month (2025)

In 2025, AOE reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Interviews with Outstanding Authors (2025)

In 2025, many authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors, with a brief interview of their thoughts and insights as authors. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

AOE Annual Report (2024)

Dear all,

We are pleased to share with you the 2024 annual report of Annals of Esophagus (AOE). In 2024, with the joint effort and support of all contributors, AOE was indexed by Web of Science and increased website pageviews and visitors. For more details, please see the following report.

Interviews with Editorial Board Members

AOE features a distinguished editorial board, the members of which continue to instill the power of their expertise for the journal’s development. By launching this column, we are glad to introduce to you some of them in the form of interviews, in which they will share their unique career experiences and perspectives. We believe their insights will shed light on the knowledge of related fields.

AOE is officially indexed by Emerging Sources Citation Index (ESCI)

On March 20, 2024, a confirmation letter reached the editorial office of The Annals of Esophagus (AOE) that the journal met the selection criteria necessary to be included in the Emerging Sources Citation Index. Articles published in AOE after 2021, beginning with Vol 5, will be included in Emerging Sources Citation Index.

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Cover image "Bamboo V" by Dr. Anthony P Yim, MD More >>

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Case Report

Peptic esophageal perforation in Zollinger-Ellison syndrome: a case report of a rare and severe complication

Arianna Vittori, Andrés R. Latorre-Rodríguez, Hideyuki Takeuchi, Sumeet K. Mittal

Annals of Esophagus

2025;

(30 September 2025)

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Review Article

Advances in the medical management of esophageal cancer: an updated narrative review

Adithya Nagendran, Anushree Venkatesh Murthy, Devika Rao

Annals of Esophagus

2025;

(30 September 2025)

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Review Article

Current and novel treatment approaches for locally advanced esophageal squamous cell carcinoma: a narrative review

Margaret Comer, Hubert Chen, Margaret C. Wheless, Michael K. Gibson

Annals of Esophagus

2025;

(30 September 2025)

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Review Article

The evolving role of systemic therapy in locoregionally advanced esophageal cancer: a narrative review

Mariya L. Samoylova, Ravi Rajaram

Annals of Esophagus

2025;

(30 September 2025)

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Original Article

Esophagectomy for end-stage achalasia: functional and quality of life outcomes

Nikhil R. Kundu, Tanya Irvine, David I. Watson, Jennifer C. Myers, Peter G. Devitt, Sarah K. Thompson

Annals of Esophagus

2025;

(30 September 2025)

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Original Article

Physical functioning of patients undergoing neoadjuvant treatment for cancer of the oesophagus and the subsequent impact of exercise prehabilitation—results of a cohort study within the PREHIIT trial

Linda O’Neill, Emily Smyth, Neil Kearney, Grainne Sheill, Louise Brennan, Sarah Wade, Sophie Grehan, Sanela Begic, Ross T. Murphy, Myles McKittrick, Suzanne L. Doyle, John V. Reynolds, Juliette Hussey, Emer Guinan

Annals of Esophagus

2025;

(30 September 2025)

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Original Article

Minimally invasive hiatal hernia repair: a single-institution experience and evolving surgical trends

Fadi Alsayegh, Jessica E. Wahi, Jacob Kalathoor, Fernando M. Safdie

Annals of Esophagus

2025;

(30 September 2025)

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Original Article

Health state utility values in esophageal cancer: a systematic review and meta-analysis

Josipa Petric, Victoria Kollias, Sonia Hines, Muktar Ahmed, Maziar Navidi, Tim Bright, Jonathan Karnon, David I. Watson, Norma Bulamu

Annals of Esophagus

2025;

(30 September 2025)

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Editorial Commentary

Esophageal epiphrenic diverticulum: principles of management and decision making

Kamal Kabaha, Yehonatan Nevo

Annals of Esophagus

2025;

(30 June 2025)

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Case Report

A case report of esophageal squamous cell carcinoma with schwannoma-like features: from diagnosis to surgical management

Danika E. Meldrum, Rashmi Kumar, Chigozirim N. Ekeke

Annals of Esophagus

2025;

(30 June 2025)

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Review Article

Expert opinion on the management of esophageal achalasia from the Society for Surgery of the Alimentary Tract (SSAT) Global Outreach Committee

Fernando A. M. Herbella, Amber L. Shada, Júlio Rafael Mariano da Rocha, Ulysses Ribeiro Jr, Viv Velanovich, Renato Salvador

Annals of Esophagus

2025;

(30 June 2025)

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Review Article

The rise of robotic-assisted esophagectomy: a game-changer or just an added cost—a narrative review

Andrei I. Gritsiuta, Roman V. Petrov

Annals of Esophagus

2025;

(30 June 2025)

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Review Article

An update on developments in curative treatment for locally advanced esophageal cancer: a narrative review

B. Feike Kingma, Cezanne D. Kooij, Jelle P. Ruurda, Richard van Hillegersberg

Annals of Esophagus

2025;

(30 June 2025)

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Review Article

Physiologic and molecular effects of alcohol in the esophagus: a narrative review

Anisa Shaker

Annals of Esophagus

2025;

(30 June 2025)

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Review Article

A review of esophageal cancer research: emerging trends, progress and perspectives

Norhan Turki, Arshia Sharma, Laura J Roney, Malaika Wauters, Evan Grapilon, Risca Li, Ali Zifan

Annals of Esophagus

2025;

(30 June 2025)

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Editorial Commentary

The role of neoadjuvant immunotherapy in nonsurgical candidates with locally advanced esophageal squamous cell carcinoma

Juhi Gor, Shikha Jain

Annals of Esophagus

2025;

(30 March 2025)

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Editorial Commentary

Cracking the code of early esophageal cancer detection

Mickael Chevallay, Stefan Monig

Annals of Esophagus

2025;

(30 March 2025)

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Editorial Commentary

Predicting pathological response to neoadjuvant therapy in esophageal cancer

Puja Gaur Khaitan, Laurette Lecharlois Bukasa, Balamurugan Rathinavelu

Annals of Esophagus

2025;

(30 March 2025)

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Editorial Commentary

Translational potential of SENP1 in esophageal squamous cell carcinoma

No’ad Shanas, Kelly A. Whelan

Annals of Esophagus

2025;

(30 March 2025)

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Editorial Commentary

Beyond survival: understanding long-term quality of life after esophageal cancer treatment

Sri Sivarajan, Bhaskar Kumar

Annals of Esophagus

2025;

(30 March 2025)

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Review Article

Pepsin properties, structure, and its accurate measurement: a narrative review

Kyle J. Stanforth, Matthew D. Wilcox, Peter I. Chater, Iain A. Brownlee, Maria I. Zakhour, Katherine M. R. M. Banecki, Jeffery P. Pearson

Published online: 25 September 2022

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Review Article

Pathophysiology of achalasia

Amanda B. Rogers, Benjamin D. Rogers, C. Prakash Gyawali

Published online: 25 September 2020

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Review Article

The upper esophageal sphincter: anatomy and physiology

Apoorva T. Ramaswamy, Per Martell, Renata Azevedo, Peter Belafsky

Published online: 25 September 2022

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Review Article

Surgical treatment of Siewert type II gastroesophageal junction cancer: esophagectomy, total gastrectomy or other options?

Gabriel Saliba, Masaru Hayami, Fredrik Klevebro, Magnus Nilsson

Published online: 25 June 2020

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Review Article

Pneumatic balloon dilatation for achalasia—how and why I do it

Tim Bright

Published online: 25 September 2020

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Review Article

A narrative review of the prevalence of gastroesophageal reflux disease (GERD)

Katie H. A. Boulton, Peter W. Dettmar

Published online: 25 March 2022

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Review Article

Diagnosis and treatment of pseudoachalasia: how to catch the mimic

Dylan R. Barnett, George L. Balalis, Jennifer C. Myers, Peter G. Devitt

Published online: 25 June 2020

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Review Article

Achalasia subtypes are front and center of the Chicago classification—strategies to overcome limitations in clinical application

Jennifer C. Myers, Charles Cock

Published online: 25 September 2020

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Review Article

Stretta therapy in the management of gastroesophageal reflux disease (GERD)

Dalbir S. Sandhu, Ronnie Fass

Published online: 28 February 2019

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Review Article

Anastomotic leakage after esophagectomy for esophageal cancer: risk factors and operative treatment

Sander Ubels, Moniek H. P. Verstegen, Camiel Rosman, John V. Reynolds

Published online: 25 March 2021

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Review Article

Role of botulinum toxin injection in treatment of achalasia

Richard Heddle, Charles Cock

Published online: 25 September 2020

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Case Report

Recurrent esophageal candidiasis: a case report of different complications

Siok Siong Ching, Teik Wen Lim, Ya-Lyn Annalisa Ng

Published online: 25 March 2021

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Mini-Review

Collis gastroplasty: why, when and how?

Pietro Riva, Lee L. Swanström

Published online: 26 September 2018

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Review Article

High-grade dysplasia of the esophagus: when is it time for surgery? —a systematic review

Stephanie G. Worrell, Katie E. Bingmer, Asya Ofshteyn, Christopher W. Towe, Yaron Perry, Philip A. Linden

Published online: 25 March 2020

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Review Article

Managing recurrent symptoms after treatment of achalasia

David I. Watson

Published online: 25 June 2020

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Editorial

IgG₄ in eosinophilic esophagitis: perpetrator, accomplice or bystander?

Kelly O’Shea, Simon P. Hogan

Published online: 30 September 2018

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Review Article

Minimally invasive surgery: hiatal hernia repair—a narrative review

Lina Hua, Geoffrey P. Kohn

Published online: 25 December 2022

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Review Article

Esophagectomy for end-stage achalasia—is it too aggressive?

Nikhil R. Kundu, Sarah K. Thompson

Published online: 25 September 2020

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Review Article

A narrative review of functional dysphagia—what we know so far

Paul M. Travers, Ting Zheng, Kenneth R. DeVault, Maoyin Pang

Published online: 26 December 2024

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Case Series

The role of anti-reflux surgery in refractory peptic strictures—case series

Leeying Giet, Andrea De Zanna, Mohamed Saad Aboul Enein, William Knight, James A. Gossage

Published online: 27 September 2024

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Journal Highlight more

Annals of Esophagus is an international, peer-reviewed, open-access journal focusing on basic and clinical research in all fields pertaining to the esophagus, including but no limited to esophageal cancer, Barrett's esophagus, gastroesophageal reflux disease, achalasia, hiatal hernias, esophagitis, congenital esophageal disease, esophageal diverticulum, esophageal perforation, benign esophageal neoplasms, and other rare esophageal malignancies.